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lab-bench

DiscoveryLab Targets

The targets being pursued by research leaders at the University of Alberta include novel drivers for cancer, diabetes, infection, inflammation, cardiovascular and genetic diseases. They include kinases, phosphatases, GTPases, signaling proteins, lipid binding domains and transmembrane proteins using SMALP technology.

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Cell Adhesion systems

including desmogleins, plakins, plakoglin and their partners involved in skin blistering diseases, cardiomyopathies and cancer

Deacetylases

Glyco-enzymes

GTPases

including Arf1, Cdc42, FGD5, RhoA, Rac1, Rac2 and their GEFs

Lipid enzymes

Kinases

Nucleic Acid Recognition

Oxygenases

Phosphatases

including CD45, LPP2, PP1C, PTP1B, SHP1, SHP2 and their regulators

Prion-related proteins

Proteases

including ADAMs, rhomboid proteases, MMPs and regulators including TIMPs

Transmembrane systems

Ubiquitination